Paget’s disease of the breast is a rare kind of breast cancer that mostly affects the skin around the nipple. It happens in only a small number of breast cancer cases because it’s linked to ...

In Paget’s disease, the balance between bone removal and bone building gets disrupted. Bone building begins to occur at a faster pace than bone removal. The resulting new bone is brittle, weak ...

Paget’s disease of the vulva is a rare type of skin disease that develops on the vulva. It is very slow to spread and is typically found in women who have been through menopause. In some cases, ...

The disease seems to occur in one of two patterns: monostotic (localized) and polyostotic (generalized). In humans, the most commonly affected bones are the pelvis, skull, femur, spine, tibia ...

People living with Paget’s are at increased risk of fractures, so identify and remove any tripping hazards in the home.

X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

Dear Doctors: I was recently diagnosed with Paget’s disease after suffering fatigue symptoms and muscle soreness in my neck, pelvic and lower-leg areas. I am sore and lethargic upon waking up in the ...