Before the discovery of agents that specifically inhibited osteoclastic bone resorption, there was no effective treatment for Paget's disease. This situation changed with the development for ...

X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

The disease seems to occur in one of two patterns ... right infraorbital fissure, right maxillary bone, lacrimal bone, malar process and zygomatic bone. These bones were soft, suggesting that ...

Symptoms of Paget’s disease include the fatigue and discomfort you have experienced. Sometimes, changes to bone shape are visible. People living with Paget’s are more susceptible to bone ...

What can you tell me about Paget’s, treatments and research advances? Dear Reader: The full name of the condition you have been diagnosed with is Paget’s disease of bone. Also known as osteitis ...

It fills in the gaps with new bone, which renews and strengthens the skeletal structure. In Paget’s disease, the balance between bone removal and bone building gets disrupted. Bone building ...

Dear Doctors: I was recently diagnosed with Paget’s disease after suffering fatigue symptoms and muscle soreness in my neck, pelvic and lower-leg areas. I am sore and lethargic upon waking up in ...

Ipriflavone can block part of the process that leads to bone loss. A bone disease that can cause pain (Paget disease). Early research shows that taking ipriflavone might decrease bone pain in some ...