Microtubules provide structural support to neurons and microtubule stability is regulated through association with a protein known as tau. Tau is expressed in the central nervous system (CNS ...

Tau is a protein that builds up and moves between nerve cells in the brains of people living with Alzheimer’s disease, causing damage. Professor Mudher is using clever genetic manipulation in fruit ...

The study also showed that female participants may be more at risk of a heavier buildup of tau protein than male participants. We were surprised to see that people with a father with Alzheimer's ...

The present work is undertaken to enhance our understanding of the pathogenesis of Alzheimer’s disease ... Finally, we test our hypothesis that unbalanced expression of tubulin and tau leads to ...

The amyloid cascade hypothesis that deposition of Aβ in the brain initiates Alzheimer's disease pathogenesis, "leading to subsequent tau deposition ... ApoE protein is a lipid-binding protein ...

Abnormal accumulation of tau protein in the brain has been associated with neurodegeneration and cognitive decline in AD patients. BIIB080 is an investigational antisense oligonucleotide therapy ...

An oral small molecule from New York-based biotech Oligomerix curbed the tangling of tau protein in the brains of mice that model a rare neurological disease. The results, published on March 12 in ...

However, research has also linked glutamate to the toxic accumulation of tau protein – a hallmark of neurodegenerative diseases like Alzheimer’s. A recent study led by scientists at USC Stem Cell, ...

Aβ accumulation and plaque formation are central to AD pathogenesis. CD2AP has been found to regulate Aβ metabolism by controlling the trafficking and degradation of amyloid precursor protein (APP).