Certain drugs and a host of nonpharmacologic therapies are key to treating patients who have nociplastic pain, a relatively ...

In the second world war, the physician Henry Beecher observed that some of his soldier patients, despite being injured on the ...

[5] A very schematic view of pain transmission is shown in Figure 1. A tissue injury leads to the activation of peripheral nociceptors, primary afferents and their central targets. This amplified ...

Several factors influence the frequency and severity of chronic peripheral neuropathic pain, including type and dose of chemotherapy, pre-existing neuropathy, and the use of other drugs that can ...

"What we have developed is potentially a gene therapy approach for chronic pain ... interfere with nociceptors, making it more difficult for the sensory neurons to transmit pain information ...

Treating nociceptors with TSP1 suppressed their pain signaling. The researchers think that TSP1 may help restore balance, ...

The US Food and Drug Administration (FDA) announced its approval of a non-opioid treatment for moderate–severe acute chronic pain. The drug ... Na V 1.8, expressed in pain-sensing neurons (nociceptors ...