Widespread alterations in RNA processing (splicing, polyadenylation, decay, etc.) are common in dynamic cell states during development and malignancy. For example, many cancers harbor elevated levels ...

The processing of the 3' end adds a poly ... A polymerase adds a chain of adenine nucleotides to the RNA. This process, called polyadenylation, adds a poly-A tail that is between 100 and 250 ...

Yet, sometimes 3'-end processing factors start polyadenylation earlier in the transcript ... empower scientists mapping the RNome and advance our overallunderstanding of RNA. Tecan Group (SIX Swiss ...

The Lai lab uses an integrated approach to study selected topics in mRNA processing and modification, including alternative polyadenylation, circularization and RNA methylation. As a core member of ...

regulates alternative cleavage and polyadenylation of mRNAs. "Our team has identified a gap in knowledge around the RNA-binding capabilities of C2H2 zinc finger proteins," said Jack Greenblatt ...

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...

Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

One of the most abundant and significant modifications in RNA is m6A, which influences RNA processing, stability, and translation into proteins. However, its role in cancer—particularly prostate ...

which binds to specific promoter regions on the DNA and initiates the synthesis of the complementary RNA strand. The resulting primary transcript, known as pre-mRNA in eukaryotes, undergoes several ...

RNA-targeted Cas9 may support countless other efforts for studying the role of RNA processing in disease or for identifying drugs that reverse defects in RNA processing,” study coauthor David Nelles ...

For each protein, its corresponding RNA genomic segment is indicated ... CPSF30: 30-kDa cleavage and polyadenylation specificity factor; F2: Frame 2; HA: Hemagglutinin; IFN: Interferon; M1 ...