Protein–protein interaction networks are the networks of protein complexes formed by biochemical events and/or electrostatic forces and that serve a distinct biological function as a complex.

The availability of large-scale protein-protein interaction data has led to the recent popularity of the study of protein interaction networks. Just as the enormous amount of available sequence ...

A novel geometric deep learning framework designs ligand-specific protein binders, enhancing therapeutic potential in cell therapies and synthetic biology.

As well as being essential in the precise packaging of DNA into the space of the nucleus, histone proteins are also the site ...

Evolution has been fine-tuning life at the molecular level for billions of years. Proteins, the fundamental building blocks of life, have evolved through this process to perform various biological ...

New research has investigated the mechanism by which bivalency functions to poise genes for expression during cell differentiation, providing insight into a long-standing paradigm in the regulation of ...

Modeling Protein-Protein Interactions for Future Drug Discovery Collaborating with Dr. Haiyuan Yu, director of the Cornell ...

Their environments—water, lipid membranes, or other condensed phases—are critical to their function, shaping their structure and interactions. Yet many modern protein-design methods ...

Proteins, the pillars of cellular function, often assemble into 'complexes' to fulfill their functions. A study reveals why this assembly often begins during the very process of protein synthesis or ...

To uncover the sites of protein-DNA interactions at genome scale, Bing Ren, a former postdoctoral researcher in Young’s lab and now a gene regulation researcher at the University of California, San ...

It has been a few years since AI began successfully tackling the challenge of predicting the three-dimensional structure of proteins, complex molecules that are essential for all life. Next-generation ...