To characterize the contributions of individual amino acids to the structure or function of a protein, researchers have adopted directed evolution approaches, which use iterated cycles of ...

The three-dimensional shape of a protein determines its function. This is because proteins form attachments and interact with many other molecules and structures inside organisms. The shape of a ...

One such molecular switch is G protein-coupled receptor kinases, or GRKs for short ... revealing the intricate mechanisms by which they function. The ability to physically look at proteins ...

Delve into the kinase inhibitors' diverse landscape, from cancer breakthroughs to autoimmune disease innovations.

Researchers at the Leibniz Institute on Aging—Fritz Lipmann Institute (FLI) in Jena have discovered a new function of the DNA repair protein ATR in regulating mitochondrial homeostasis.

The scientists discovered that a total of 159 different protein kinases—around a third of ... In addition, it was shown that ...

The protein, called Aurora-A, is one of a group of proteins called kinases. Kinases are enzymes ... with TACC3 without inhibiting the enzymatic function of Aurora-A. Excitingly, the team also ...