This innovation could help accelerate drug discovery and enhance the efficiency ... analogous to how palladium cross-coupling revolutionized pyridine chemistry decades ago," said Hans Renata ...

Because many drugs are excreted in human milk, a decision should be made to discontinue nursing or to discontinue the drug, taking into account the importance of drug therapy to the mother.

A molecular glue drug, discovered following a program of ... Armed with this information, the team tried replacing the pyridine in CR8 with a broad range of substitutes. They first tried using ...

2-a]pyridine-3-carboxylic acid and (4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl) phenyl)methanamine. The drug has no chiral center, is amenable to large-scale synthesis and has a low cost of ...