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Epstein-Barr virus aggravates ulcerative colitis via macrophage pyroptosis: Findings could yield new therapeutic target
The study revealed that EBV infection dramatically increases the levels of pyroptosis-related proteins, including Gasdermin D, NLRP3, interleukin-1β (IL-1β), and interleukin-18 (IL-18), in the ...
EurekAlert!26d
Epstein-Barr virus worsens ulcerative colitis by triggering macrophage pyroptosis through glycolysis
Epstein-Barr virus infection induces the upregulation of glycolysis in intestinal macrophages, which subsequently activates Gasdermin D, NLRP3 ... infection activates pyroptosis—a form of ...
Business Wire1mon
Ventus Therapeutics Announces First Patient Dosed in Phase 2a Clinical Trial Evaluating VENT-02, an Oral, Brain-Penetrant NLRP3 Inhibitor, in Parkinson’s Disease
WALTHAM, Mass. & MONTREAL--(BUSINESS WIRE)--Ventus Therapeutics, a clinical-stage biopharmaceutical company with two novel small-molecule programs entering Phase 2 development for immunological ...