Active caspase 1 causes pyroptosis and is responsible for proteolytic maturation of the inflammatory cytokines interleukin-1β (IL-1β) and IL-18. Pyroptosis is characterized by caspase 1 ...

A recent study has revealed how Epstein-Barr virus (EBV) intensifies ulcerative colitis (UC), a debilitating inflammatory bowel disease.

The study revealed that EBV infection dramatically increases the levels of pyroptosis-related proteins, including Gasdermin D, NLRP3, interleukin-1β (IL-1β), and interleukin-18 (IL-18), in the ...

Epstein-Barr virus infection induces the upregulation of glycolysis in intestinal macrophages, which subsequently activates Gasdermin D, NLRP3 ... infection activates pyroptosis—a form of ...