We also discuss recent advances in uncovering the proteins that act during the RNAi process, discoveries ... sequence length to achieve strong RNA interference is not yet known.

Nature Methods celebrates this anniversary by dedicating a Focus to RNA interference in mammalian ... a lot remains to be understood about the RNAi process as it occurs naturally or in response ...

In 1998, Andrew Fire and Craig Mello published a groundbreaking study demonstrating that double-stranded RNA (dsRNA) could silence genes in the nematode Caenorhabditis elegans. This discovery laid the ...

Plants and fungi can use conserved RNA interference machinery to regulate each other’s gene expression—and scientists think they can make use of this phenomenon to create a new generation of ...

Discover how RNA therapeutics are reshaping medicine, offering new treatments for previously undruggable targets.

This process is carried out by the enzyme RNA polymerase ... These RNA molecules can interact with mRNA, influencing its stability, translation, or degradation, thus fine-tuning protein production in ...

In the process, DNA is transcribed into RNA and then translated into functional proteins that subsequently undergo folding to achieve their correct structure, which is key to proper function.