hLife聚焦健康科学领域的前沿进展，旨在促进基础研究与临床应用的融合发展。期刊发表与医学相关各研究领域最新成果，学科领域包括（但不限于）病原生物学、流行病学、生理学、免疫学、结构生物学、疾病监测、肿瘤、药物、疫苗和健康政策等。

There are a variety of different types of RNA polymerases that can transcribe different types of RNA. RNA polymerase II, shown here, is responsible for creating messenger RNA (mRNA), which is the main ...

Primrose Bio announced a new product to improve the manufacturing on long-template mRNA vaccines. 1 The Prima RNApols ExTend ...

在讨论部分，研究人员指出，癌症细胞依赖过量的蛋白质合成来维持其不受限制的生长，核糖体生物发生已成为抗癌干预的新靶点。NC 作为一种天然生物碱，对多种癌细胞系和原代细胞都具有抑制增殖的作用，其机制包括抑制蛋白质合成、核糖体生物发生，破坏核仁结构，影响 rRNA 合成相关因子，以及作为 DNA 嵌入剂抑制拓扑异构酶，激活多种细胞应激反应和调控通路。此外，NC ...

Because infected host cells ordinarily lack RNA-dependent RNA polymerase (RdRp) activity, these RNA viruses encode a replicative polymerase essential for the production of progeny. Such virally ...

2025年3月12日，中国农业科学院兰州兽医研究所动物病毒分子生态学团队在《美国国家科学院院刊（PNAS）》上发表了题为“ N 6-methyladnosine of vRNA facilitatesinfluenza A virus ...

Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo.I suggest that ∼ 90% of Pol II initiation events in ...

在研究结论和讨论部分，tNGS 展现出了令人瞩目的优势。它能同时检测 DNA 和 RNA 病原体，在临床诊断中具有较高的应用价值。相比传统检测方法，tNGS 能更准确、快速地识别病原体，为临床治疗提供有力的支持。在检测一些难培养或不典型的病原体时，tNGS 的优势尤为明显。虽然 tNGS ...

The replication of the Nipah virus's genetic material in infected cells has been demonstrated for the first time by researchers from the Max Planck Institute (MPI) for Multidisciplinary Sciences and ...

Researchers have shown, for the first time, how the genetic material of the Nipah virus replicates in infected cells. The ...

To implement the blueprint it contains, RNA polymerase is used. The enzyme reads the information stored in the template and ...