Single-Molecule Footprinting reveals that RNA polymerase II (Pol II) occupancy is infrequent at mouse promoters. This results ...

Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo.I suggest that ∼ 90% of Pol II initiation events in ...

There are a variety of different types of RNA polymerases that can transcribe different types of RNA. RNA polymerase II, shown here, is responsible for creating messenger RNA (mRNA), which is the main ...

The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (pol II), governs the expression of all protein-coding and most non-coding ...

在流感病毒生命周期中，病毒基因组RNA在早期进行高效转录（vRNA ... 首次揭示了NS2通过干扰RdRp与宿主Pol II CTD结合从而抑制转录的分子机制 ...

RNA cleavage can occur either: (i) by a transesterification mechanism that yields 2’,3’-cyclic-PO 4 and 5’-OH ends; or (ii) via a hydrolytic mechanism that leaves 3’-OH and 5’-PO 4 ends. RNA repair ...

Our mission is to elucidate fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II) in normal and disease states. We are particularly interested in ...