Widespread alterations in RNA processing (splicing, polyadenylation, decay, etc.) are common in dynamic cell states during development and malignancy. For example, many cancers harbor elevated levels ...

This highly specialized structure might function as an intracellular focal domain that organizes and controls RNA processing in male germ cells. Figure 1: The CB is a dense fibrous structure in ...

RNA breaks destined for repair are inflicted by sequence-specific or structure-specific endoribonucleases during physiological RNA processing (e.g. tRNA splicing; kinetoplast mRNA editing) and under ...

Scientists at the UCLA Health Jonsson Comprehensive Cancer Center and the University of Toronto have revealed how a tiny ...

This study shows that RNA decay rather than the presence of premature termination codons triggers a TA-like response.

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

Scientists have revealed how a tiny chemical modification in RNA, known as m6A, plays a critical role in the progression of ...

Scientists at the UCLA Health Jonsson Comprehensive Cancer Center and the University of Toronto have revealed how a tiny chemical modification in RNA, known as m6A, plays a critical role in the ...

A research team from the University of Barcelona's Institute of Neurosciences described a novel molecular mechanism that modifies protein synthesis and impacts RNA processing in Alzheimer's ...

which binds to specific promoter regions on the DNA and initiates the synthesis of the complementary RNA strand. The resulting primary transcript, known as pre-mRNA in eukaryotes, undergoes several ...

This important study offers a molecular characterization of neurons and glia in the adult nervous system of the fruit fly Drosophila melanogaster. The study focuses on the progeny of a specific set of ...