RNA 是尚未开发的药物靶标的巨大宝库。基于结构的虚拟筛选 (VS) 利用结合位点信息识别候选分子，传统上采用分子对接模拟。然而，对接很难在大型化合物库和 RNA 靶标中扩展。

“RNA有很多家族，此前在解析RNA结构时，科研人员往往不确定应该选择哪些序列进行解析。”复旦大学智能复杂体系实验室研究员、文章共同通讯作者孙思琦解释道， “这就像开‘盲盒’，我们只能猜测哪些家族的序列可能具有稳定的结构。” ...

核酸适配体作为靶向药物分子，在癌症治疗和药物开发等领域展现出广阔的应用前景。其中，L-RNA 适体是一种非天然核酸适配体，具有很强的生物稳定性，可以抵抗核酸酶的降解。目前，已有基于 L-RNA 的核酸适配体进入临床阶段。L-RNA ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

In the process, DNA is transcribed into RNA and then translated into functional proteins that subsequently undergo folding to ...

NuFold is a groundbreaking tool for more accurate and efficient RNA structure prediction, with the potential to significantly advance RNA research. Subscribe to Technology Networks’ daily newsletter, ...

Researchers have shown, for the first time, how the genetic material of the Nipah virus replicates in infected cells. The ...

NuFold is a groundbreaking tool for more accurate and efficient RNA structure prediction, with the potential to significantly advance RNA research. In order to sustain life, varieties of molecules ...

The replication of the Nipah virus's genetic material in infected cells has been demonstrated for the first time by researchers from the Max Planck Institute (MPI) for Multidisciplinary Sciences and ...

NuFold is a groundbreaking tool for more accurate and efficient RNA structure prediction, with the potential to significantly advance RNA research. In order to sustain life, varieties of molecules ...