Although previous work identified isolated examples of circular forms of RNA, a new study in PLoS ONE shows that the molecule assumes this shape much more than previously thought. By surveying the ...

The poly-A tail is a long chain of adenine nucleotides that is added to a messenger RNA (mRNA) molecule during RNA processing to increase the stability of the molecule. Immediately after a gene in ...

Lee and Glaunsinger showed that wild type SOX — but not mutant SOX, which causes a defect in RNA turnover — induces ... was necessary for aberrant tail lengthening. As these PABPs are involved ...

A new review article highlights the transformative role of circular RNA (circRNA) in cancer, revealing its potential as both ...

Unlike traditional messenger RNA, circRNAs form a continuous loop, lacking the typical 5' cap and 3' tail. This unique structure was originally believed to preclude them from protein translation.

RNA, or ribonucleic acid, is a essential biological molecule that plays a crucial role in various cellular processes. It is a polymeric molecule composed of nucleotides, each containing a ribose sugar ...

Johns Hopkins scientists have developed an mRNA “booster” as a potential new way to treat rare genetic diseases marked by too ...

Messenger RNA carries genetic information from DNA in the highly protected nucleus out to the rest of the cell, where structures called ribosomes can build proteins according to the DNA blueprint.

A new review article highlights the transformative role of circular RNA (circRNA) in cancer, revealing its potential as both a key player in tumor ...