2018 saw a breakthrough in the field of RNA interference (RNAi), when the US FDA approved the first drug using this gene-silencing mechanism. Five years and five more approved drugs later ...

This discovery laid the foundation for understanding the RNAi mechanism and its potential applications. Fire and Mello were awarded the Nobel Prize in Physiology or Medicine in 2006 for their work on ...

If both message and protein are ablated, the response is 'classical' RNAi. In contrast, if only the protein is reduced, the chances are that a miRNA-related translational mechanism is at work.

Her writing focuses on gene editing technology, cell and gene therapies, and the regulatory space. View Full Profile. Learn about our Editorial Policies. The natural RNAi mechanism can be directed by ...

We believe the exquisite specificity afforded by the RNAi mechanism of action and our industry-leading, proprietary GalNAc-conjugate approach for delivery to the liver is an unparalleled ...

RNA interference (RNAi), meanwhile, is a natural defense mechanism against exogenous genes but can counter the positive effects of mRNA. The new proof of concept study published in ACS Nanoscience ...

McNamara, PhD, executive director, Office of Technology Management, University of Massachusetts Medical School. "The Tuschl I patent is a critical invention by Professors Tuschl, Zamore, Bartel, and ...

Elucidation of molecular mechanisms of viral replication and signal transduction pathways involved in viral pathogenesis, have opened new avenues for the development of alternative therapeutic ...

Alnylam has said it will not proceed with a clinical trial of its RNAi drug vutrisiran in the ... disease would prompt the pricing negotiation mechanism. Alnylam's earlier plan was to start ...