2014年12月， 复旦大学附属肿瘤医院 在Oncotarget期刊上发表了一篇论文。在 发表4年后 ，因 图片组内重复 在pubpeer上被读者质疑。 论文题为 “Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor ...

Figure 5: Cell-survival pathways downstream of activated erbB receptor tyrosine kinases. The Ras–MAPK (mitogen-activated protein kinase ... on screening for RTK inhibitors, and reinforces ...

On the left, an unactivated RTK receptor (pink ... Signal binding to membrane receptor tyrosine kinases (RTKs) activates an enzyme called a kinase. Learn how kinases initiate a signaling cascade ...

Another RTK of interest is MuSK, which is expressed exclusively in muscle cells and ... Read more in our paper “Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the ...

I study and characterize the response to KRAS G12C, SOS1 and SHP2 inhibitors alone or in combination with receptor tyrosine kinase (RTK) or MEK inhibitors in different tumor types to determine the ...

This manuscript provides a comprehensive overview of potential resistance mutations within MET Receptor Tyrosine Kinase and defines how specific mutations affect different inhibitors and modes of ...

Members of the RTK family include, among others, the insulin and insulin-like growth factor ... We are also studying the molecular mechanisms by which JAK2, a member of the Janus kinase family of ...

Background Tyrosine kinase 2 (Tyk2) is a member of the JAK family that phosphorylates STAT proteins downstream of the IL-12, IL-23 and the Type I interferon receptor. Tyk2 genetic variants have been ...