On the left, an unactivated RTK receptor (pink ... Signal binding to membrane receptor tyrosine kinases (RTKs) activates an enzyme called a kinase. Learn how kinases initiate a signaling cascade ...

Activating mutations of receptor tyrosine kinases ... pathogenic mutations in the RTK fibroblast growth-factor receptor-2 (FGFR2). Measuring the intrinsic kinase activity of several pathogenic ...

Investigators conducted a retrospective review that spanned 10 years with the goals of describing the clinical ...

Hypomethylation on fibroblast growth factor receptor 2 (FGFR2), a receptor tyrosine kinase (RTK) oncogene, increased transcript and protein abundance and drove cancer activity. Genetic mutations in ...

Genetic mechanisms of resistance to kinase inhibitors include mutations in the target receptor and mutations or gene amplification of compensatory receptors or other signaling effectors.

I study and characterize the response to KRAS G12C, SOS1 and SHP2 inhibitors alone or in combination with receptor tyrosine kinase (RTK) or MEK inhibitors in different tumor types to determine the ...

2014年12月， 复旦大学附属肿瘤医院 在Oncotarget期刊上发表了一篇论文。在 发表4年后 ，因 图片组内重复 在pubpeer上被读者质疑。 论文题为 “Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor ...

Conclusion: The tyrosine kinase inhibitors sorafenib and sunitinib offer improved outcomes for patients with mRCC, but they are far short of a cure. Despite the introduction of sorafenib and ...