During the progression of atherosclerosis, development of plaques is initiated by the arterial accumulation and oxidation of low-density lipoproteins (LDLs). This initiates an inflammatory process ...

Acute coronary events frequently result from atherosclerotic plaque rupture at apparently noncritical sites. Although pathologic examination shows that specific plaque characteristics correlate ...

In atherosclerosis, the vascular smooth muscle ... process that provides an essential fibrous cap that prevents plaque rupture. With the recognition of the essential involvement of VSMC ...

COVID-19 accelerates the progression of atherosclerotic plaques, increasing coronary inflammation and the risk of high-risk ...

[14] However, they are unable to provide information on cell biologic evens that determine risk of plaque rupture. Different constituents of atherosclerosis, including radiolabeled lipoproteins ...

Atherosclerotic plaques form over decades through the deposition of blood lipids such as cholesterol in the innermost layer of the vessel wall. As the plaques become unstable and rupture ...

with a correspondingly thin fibrous cap — a vulnerable plaque prone to rupture and thrombosis. Atherosclerotic plaques typically progress to the advancing atheroma stage at age 55 years to 65 years.

Tissue factor, a key protein component of the clotting cascade, is located, among many other places, within the necrotic core of atherosclerotic plaques. With “plaque rupture” or “plaque ...

These findings indicate the development of vulnerable atherosclerotic plaques that are at higher risk of rupture. Conversely, they observed a reduction in plaque size and an induction in the ...