The work revealed that the SOS1–GFP fusion protein was on the vacuolar membrane, called the tonoplast, as well as on intracellular membranes and the plasma membrane. This result was further ...

Son of sevenless homolog 1 (SOS1) is an essential guanine nucleotide exchange factor (GEF) in KRAS-driven tumors, and it also functions as a downstream node protein of BCR-ABL, suggesting its critical ...

Bayer announced initiation of a phase I clinical trial with BAY3498264, an investigational oral selective Son of Sevenless Homologue 1 (SOS1) inhibitor. The open-label, first-in-human, dose escalation ...