Primary bile acids had little effect, except for one called TCDCA, which induced oxidative stress—a molecular imbalance that can lead to cell and tissue damage. Secondary bile acids were much ...

Hepatic synthesis of bile acids is the primary pathway for cholesterol catabolism. The cholesterol 7α-hydroxylase enzyme (encoded by CYP7A1) represents the rate-limiting step of the multi ...

“7α-dehydroxylated bile acids are notably diminished in inflammatory ... notion that restoring the balance between primary BAs and secondary 7α-dehydroxylated BAs could stimulate regeneration ...

Secondary sclerosing cholangitis (SSC) is a chronic cholestatic biliary disease, characterized by inflammation, obliterative fibrosis of the bile ducts, stricture formation and progressive ...