The beta amyloid peptide (Abeta) is the primary component of the senile plaques observed in the brains of Alzheimer's patients, and this peptide is toxic to neurons and other cells in many different ...

and more robust senile plaques than typically observed with the Swedish mutation alone (e.g. Tg-Swe). Transgenic mice containing human APP (isoform 695) containing both the Arctic (E693G) and Swedish ...