However, whether the drug can truly be called "antisense" depends on some specifics--such as the ability to bind to targeted messenger RNA (mRNA) but avoid clinging to other proteins. Representatives ...

As implied in the article by Paul Smaglik, "Making Sense of Antisense" (The Scientist, 12[17]:1, Aug. 31, 1998), the clinical usefulness of antisense compounds will be determined, in large part, by ...

In antisense group, the glomerular lesion, total cell and 24h urinary protein excretion reduce than that of control group. The level of mRNA formation of MCP-1, CCR2, TGF-β1decreased. The MCP-1 ...

Exiqon LNA™ GapmeRs are powerful tools for loss of function studies of proteins, mRNA and lncRNAs. These single strand antisense oligonucleotides catalyze RNase H-dependent degradation of ...