Penn researchers are developing new treatments using mRNA technology to combat a range of diseases, namely celiac disease ...

When this happens during DNA replication, the result is an unpredictable change in the nucleotide sequence of an organism's DNA. This process, called mutation, is part of what determines changes ...

Leftover drops in vials of Moderna’s COVID-19 vaccine allowed a group of researchers from Stanford University to determine the sequence of the mRNA for SARS-CoV-2’s spike protein that is used in the ...

How do cis-acting elements within the mRNA sequence promote or inhibit mRNA decay? We need to identify more of the factors binding to these elements and to study their interactions with the ...

When Xiao Wang applied to faculty jobs, many of the institutions where she interviewed thought her research proposal - to ...

Data on mRNA vaccines sent by Moderna to European regulators before the COVID-19 outbreak included early tests of the mRNA ...

mRNA can be used as a therapeutic tool to replace missing or defective proteins in diseases caused by genetic mutations. By delivering mRNA encoding the correct protein sequence into cells, it is ...

2 In Mercer’s latest work published in Nature Communications, his team developed a streamlined method called VAX-seq to analyze mRNA vaccines using long-read nanopore sequencing. 3 Their method ...

When a gene is to be expressed, the base sequence of DNA is copied or transcribed into mRNA (messenger RNA). This process takes place in the nucleus and occurs in a series of stages. The two ...

Each mRNA has a tail made up of a string of adenosines ... RNA's tail to be lengthened when it is outside of the nucleus: a ...

2005-2010: Improvements in mRNA synthesis, purification, and stability through chemical modifications and sequence optimization. 2010-2015: Development of lipid nanoparticle delivery systems for ...