Here, we explored how NMDARs signal in tLTD. We found that, regardless of frequency, L5 PC→PC tLTD relies on the non-ionotropic preNMDAR signaling pathway mediated by JNK2, which helps to resolve the ...

A study in mice reveals key interactions between proteins involved in fibroblast growth factor signaling and how they contribute to distinct stages of eye lens development.

Previous work by the team had shown that the NOTCH signaling pathway played a central role ... is involved from the very start of the CD8 + T cell differentiation period, which lasts around ...

In a study of the immune systems of mice, scientists at Johns Hopkins Medicine say they have found a new role for a protein, ...

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are ...

Organoids are made to model human organs and are promising for research and therapy, but there are limitations in their growth and function. A recent study found that placenta-derived IL1 under ...

Drugs harnessing the power of white blood cells in the immune system can be used to treat certain cancers and autoimmune ...

The Wingless (Wg) signaling pathway is known to be responsible for one of these constrictions, but until now the underlying mechanism regulating this was not known. "We knew that Wingless ...

Scientists at CNIC have identified a specialized group of neutrophils in the skin that produce extracellular matrix. This ...

Vividion Therapeutics, Inc. (Vividion) today announced that the first patient has been dosed in a Phase I clinical trial ...