Signal transduction describes the process of conversion of external signals, such as hormones, growth factors, neurotransmitters, and cytokines, to a specific internal cellular response ...

近日，上海交通大学医学院附属仁济医院肿瘤介入科团队在国际权威期刊《Signal Transduction and Targeted Therapy》（STTT, IF=40.8）上发表了一项重磅研究，为使用肝癌一线药物仑伐替尼耐药的肝细胞癌（HCC）患者带来了新的希望。这项题为“Efficacy and safety of lenvatinib plus ...

If there is one thing that is known about the mechanisms that govern signal transduction, it's that not very much is known. When signaling molecules bind to a cellular receptor, they set off a chain ...

Detailed biophysical and computational studies on one such interaction reveal a marvelously intricate, temporally regulated, multistep conduit for signal transduction in the cell cycle.

Unique Pharmacological Profile: In biochemical and cellular assays, ATI-2138 demonstrated a similar high potency for inhibiting both ITK and JAK3, compared to ritlecitinib which was markedly less ...

DIRECT EFFECTS: Steven Hebert, left, and Edward Brown and colleagues found that Ca 2+ receptors influence signal transduction. "Although the importance of intracellular Ca2+ ions in signal ...

Kuick Research Report Highlights Ongoing Developments In Molecular Switches Application Therapeutic Targets & Drug Delivery ...

A research team led by Dr. Tetsuya Muramoto from the Faculty of Science at Toho University has demonstrated the mechanisms by which periodic chemical signal frequencies in cells regulate gene ...

Aclaris Therapeutics (ACRS) announced the availability of a new publication describing properties of Aclaris Therapeutics’ ATI-2138, a novel ...