Stem-cell differentiation is the process by which a more specialised cell is formed from a stem cell, leading to loss of some of the stem cell's developmental potential. Stem-cell differentiation ...

During development, stem and progenitor cells gradually commit to differentiation pathways. Cell fate decisions are regulated by differentiation factors, which activate transcription programmes ...

The scientists, for example, examine how cells in the heart, blood vessel or lung tissue communicate with each other, and which signal molecules influence their function. They also look into the ...

These are found in a mature organism. Their function is to replenish all of the types of (differentiated) cells found in that specific tissue. Tissue stem cells are multipotent. This means that ...

Discovering genes and microRNAs involved in human lung development unveils IGFBP3/miR-34a dynamics and their relevance for ...

We investigate how stem cells perceive environmental changes and determine their cell fate, and how niches form and remodel the local environment during lung development, regeneration and disease ...

These cells regulate key epithelial cell processes such as proliferation, metabolism, apoptosis, senescence and differentiation ... through effects on lung cancer stem cells Upregulation of ...

Importantly, ontogeny of epidermal SCC parallels cancers associated with high mortality, including the SCC of the head and neck and the lung SCC. Tools for analysis of gene function ... the ...