CD19-directed chimeric antigen receptor (CAR) T cells are clinically effective in a limited set of leukemia patients. However, CAR T-cell therapy thus far has been largely restricted to targeting ...

Treatment of human T-ALL cell lines harboring activating ... Aberrant NOTCH1 signaling in CUTLL1 cells is dependent on γ-secretase processing of the receptor and can be effectively blocked ...

Stationed within the meninges, squads of immune cells lie in wait, ready to unleash an inflammatory assault within the brain if needed. Holding these trigger-happy troops back during peacetime falls ...

Chimeric antigen receptor-T (CAR-T) cell therapy, initially successful in hematologic malignancies ... However, TRUCKs carry a risk of severe side effects if common γ-chain cytokines are continuously ...

Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case ...

Almost 35% of drugs approved by the Food and Drug Administration work by targeting G protein-coupled receptors (GPCRs), proteins embedded in cell membranes ... functions don't rely on this ...