The TDP-43 RNA-binding protein is found in abnormal cytoplasmic inclusions in affected motor neurons in almost all ALS cases, and mutations in the TDP-43 gene (TARDBP) cause a rare form of familial ...

此前研究虽已发现血脑屏障在这些疾病中的异常，但对于其中的具体机制，尤其是内皮细胞中 TDP-43（TAR DNA-binding protein 43）蛋白水平变化与血脑屏障 ... 实现了在单细胞分辨率下同时分析核蛋白和 RNA 转录本。此外，他们还利用了单细胞 RNA 测序（snRNA-seq）、基因 ...

Researchers have developed a laboratory model that mimics the pathological aggregation of TDP-43, a key protein in ALS and frontotemporal dementia. The model, based on human cells, recapitulates ...

In 1994, a nucleic acid-binding protein was found ... in myofiber injury in IBM. “TDP-43 redistribution has the potential to alter normal translation of RNA or normal function of microRNAs ...

TAR DNA-binding protein 43, better known as TDP-43, is a protein found in almost all human cells, where it plays essential roles in regulating gene expression, RNA processing, and cellular stress ...

A key finding was the depletion of TDP-43, an RNA-binding protein genetically linked to ALS-FTD and commonly disrupted in AD. Until now, research has focused primarily on neurons, but this study ...

Domestic researchers have developed a new NANO material that can effectively inhibit the aggregation of the TDP-43 (Transactive response DNA-binding protein-43) protein, which is the cause of the ...