They bind regulatory elements of DNA such as promoters and enhancers via their DNA binding domains, and interact with various proteins via their effector domains such as coactivators or repressors.

After TFs bind to promoter or enhancer regions of the DNA, they interact with other bound TFs and recruit RNA polymerase II ... overall impact of the entire TF complex. A typical TF has multiple ...

For example, researchers know that RNA pol II can bind to a DNA sequence within the promoter of many genes, known as the TATA box, to initiate transcription. Together with other common motifs ...