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TAx9 技术:突破 Cre-loxP 系统构建难题,加速基因编辑研究进程
通过对 79 只新生小鼠的筛选,最终获得 9 只在 ROSA26 位点携带完整转基因盒的个体,成功获得了 F0 代 Cre-loxP 小鼠 。由于 F0 代个体数量有限,研究人员将 F0 代个体与野生型小鼠杂交获得 F1 代个体。对 F1 代个体的研究发现,他莫昔芬(tamoxifen)能诱导骨骼肌纤维 ...
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