Qkine无动物来源的TGF-β1、2和3具有相当的EC50值。生物活性通过在转染的HEK293T细胞中使用Promega血清反应元件(SRE)荧光素酶报告基因检测来确定。细胞用TGF-β1 PLUS(Qk010)、TGF-β2(Qk072)或TGF ...
Expression of the cell cycle inhibitor p15 INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b ...