Hypertrophic cardiomyopathy (HCM) was first described in the late 1950s as a disease typified by substantial thickening of the myocardium, particularly the left ventricular wall, with no overt cause.

Left ventricular hypertrophy (LVH) is an abnormal thickening of the left ventricular myocardium that occurs as an adaptive mechanism to increased afterload. The left ventricular myocytes ...