Receptors on the surface of cytotoxic T cells recognize peptides presented by major histocompatibility complex (MHC) molecules on the tumor cell membrane. CD8 acts as a T-cell co-receptor that ...

The findings could pave the way for more effective immunotherapy strategies, Zhang said. "In this study, we also identified several peptide antigens that are more highly expressed in cancer cells ...

However, at lower antigen doses there was a requirement ... First, should syngeneic or allogeneic dendritic cells be used for tumor peptide presentation? Mature, syngeneic dendritic cells have ...

The quest for such tumor-specific antigens (TSAs) has largely focused on predicting mutated peptides from cancer cell genomes of individual patients. This approach makes a research project out of each ...

Researchers at the Terasaki Institute for Biomedical Innovation have developed an innovative delivery system that could significantly improve the effectiveness of peptide-based cancer vaccines, ...

A personalized neoantigen cancer vaccine generated strong immune responses in renal cell carcinoma patients, leading to ...

The molecular identification of tumor antigens from human tumors and the ... These include T-cell epitope peptides, defined carbohydrates of glycoproteins and glycolipids, antibody-based anti ...

A phase 1 study of a personalized cancer vaccine demonstrated antitumor immunity in all treated patients with resected renal ...

Such HSP-peptide complexes are actively taken up by APCs and are able to stimulate antigen-specific T-cell ... the demonstration that these can induce tumor-specific T-cell responses.