In pancreatic cancer, many tyrosine ... the kinase domain and multiple phosphorylation sites. Upon binding with its ligands (EGF, transforming growth factor alpha, and amphiregulin), EGFR ...

The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs?

EGF receptor (EGFR) tyrosine kinase inhibitors (TKIs), given their low molecular weight, may be able to reach a higher concentration in brain tissues. Various reports and small studies ...

Specific inhibitors of cellular protein tyrosine kinases (genistein; Sigma), of EGFR protein tyrosine kinase (tyrphostin 1; Sigma) and of FGFR protein tyrosine kinase (SU4989 and SU5402 ...

We usually think about EGFR as the classical mutation, deletion 19 and 858R mutation. But in the last, I will say, five to 10 years, we discovered that other kinase domain mutations, such as exon ...