EGF receptor (EGFR) tyrosine kinase inhibitors (TKIs), given their low molecular weight, may be able to reach a higher concentration in brain tissues. Various reports and small studies ...

The epidermal growth factor receptor (EGFR) is a target found in high concentrations in several solid tumors including lung, breast, colorectal, and brain. Tyrosine kinase inhibitors, such as ...

The ERBB receptors are a group of receptor tyrosine ... kinase, which indicated that the kinase domain is normally under some form of inhibition. When they increased the concentration of the EGFR ...