RNAi is activated by introducing double-stranded RNA homologous to the target gene transcript. The exogenous RNA is digested in to small interfering RNAs (siRNA), which bind a nuclease complex to form ...

The VDL is currently restructuring and not providing services at this time. For all request of viral vectors, please visit the Gene Vector Core Website or send an email to [email protected]. Since ...

Reporting in Nature, Kumar and colleagues have now developed a method to target small-interfering RNA (siRNA) to the CNS, providing a safe and non-invasive approach for the delivery of this new ...

The double-stranded RNA is processed by an RNase III family enzyme Dicer, resulting in the generation of an siRNA, a 21–23-nucleotide (nt) RNA duplex, composed of a 19-mer sequence with ...