总的来说，XAI作为一项崭新的技术手段正引领着免疫学的新篇章，它不仅是解密免疫反应内在机制的强大工具，更是推动精准医疗与深度学习等前沿技术相结合的重要基石。未来，随着技术的逐步完善，XAI将在医疗、科研等多个领域展现其无尽的潜力与价值，成为行业中的一颗新星。 返回搜狐，查看更多 ...

Even in the case of uncomplicated infections, the body prepares itself early on for the possibility of a more severe course.

The tolerogenic effect of cell death depends on many factors, including the absence of T cell help, the location of the dying cells (which in part dictates their engulfment by distinct dendritic ...

Immune cells are generated to keep our bodies healthy. To combat disease, our bodies initiate two separate waves of immunity.

首先，细胞因子的分子量较小，容易通过肾脏滤过迅速从体内清除，导致其体内半衰期短。其次，细胞因子的受体在多种细胞上广泛表达，这使得系统性给药的细胞因子容易被外周细胞消耗，产生所谓的“sink effect”效应，进一步降低了在肿瘤部位的有效浓度。此外，细胞因子在体内具有细胞和功能的多样性，可能会激活一些免疫抑制性细胞亚群或信号通路，从而抵消其抗肿瘤活性，甚至引发严重的毒副作用 [1]。

文章报道了细菌鞭毛蛋白特异性受体TLR5在围产期及新生小鼠的脑膜巨噬细胞上特异性高表达, 并且揭示了TLR5激活对于新生小鼠抵抗细菌性脑膜炎感染的作用, 为神经系统巨噬细胞功能性分区的进一步研究提供了借鉴。

2025年3月26日，复旦大学生物医学研究院、附属口腔医院余红秀教授团队在Cell Death & Differentiation杂志发表了题为"SIRT7 regulates T-cell antitumor immunity through modulation of BCAA and fatty acid ...

In a recent study in mice, we found that simply perceiving hunger can change the number of immune cells in the blood, even ...

Very few humans have gone up against bird flu. But we've all dealt with seasonal flu for years. Some of our immune systems might be primed to fend off a worse case, research finds.

A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...