DNA复制是细胞分裂和个体繁殖的基础，确保了遗传信息从亲代到子代的准确传递。在真核生物中，DNA复制发生在高度动态且复杂的染色质环境中，并 ...

During DNA replication, the unwinding of strands leaves a single strand vulnerable. How does the cell protect these strands from damage? How would you identify the protein that serves as a ...

This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights ...

The first section of the book, Cellular DNA Replication, begins with an excellent overview of genome duplication by Thomas J. Kelly and Bruce Stillman, followed by chapters on specific steps in ...

Furthermore, some features of DNA replication observed in mouse ES cells are shared with human iPS cells, suggesting that the slow replication fork with high origin density may be a hallmark of ...

Within the nucleus of every cell are long strings of DNA, the code that holds all the information needed to make and control every cell within a living organism. DNA, which stands for ...

Chromosome Dynamics: Although genetic information is encoded in a one-dimensional array of DNA bases, all major DNA processes (replication, transcription and recombination) are controlled by changes ...

DNA replication, repair, and damage response, collectively called the 3Rs, support genome stability and faithful genetic inheritance. Proteins involved in the 3Rs are genome guardians that prevent a ...

Genomic instability is a hallmark of cancers and age-related diseases. Our long-term goal is to understand how cells maintain genomic integrity to regulate lifespan and avoid tumorigenesis. Emerging ...