为解决 mRNA 疫苗生产中 5′帽相关成本及稳定性问题，美国南阿拉巴马大学研究人员开展无 5′帽 mRNA 载体研究。结果显示该载体可表达 HA 并保护小鼠。此研究为 mRNA 疫苗研发开辟新方向，推荐科研读者阅读。 在当今的医学研究领域，mRNA 疫苗可谓是明星般的存在。

We therefore investigated both the immunological memory elicited by mRNA vaccination against the Timothy grass pollen allergen Phl p 5, as well as the effect of repeated challenge with aerosolized ...