propensity for structure in the denatured state and thermodynamics/kinetics of protein folding provide a wonderful transition for the beginning student from introductory biochemistry to a more ...

In 1961 the structure of one protein, myoglobin, was known at 6 Å resolution and its 2 Å structure would soon be published. The structural determinations of hemoglobin and hen lysozyme were well ...

Why do problems occur with a special variant of 'protein glues', the split inteins, that severely limit their use in producing proteins? A team has now answered this question.

Proteins are the building blocks of life. They consist of folded peptide chains, which in turn are made up of a series of ...

For those fuzzy on the details, here’s a progressive timeline that led to this monumental achievement. 1972: Anfinsen Presents the Protein-Folding Problem In science, it is often hard to pinpoint when ...

An artist's representation of a free-energy landscape and two possible paths a protein might follow (left) to fold correctly and a third path (right) that leads to a misfolded state. Disclaimer ...

et al, Insights into the interaction between UGGT, the gatekeeper of folding in ... as UGGT and the partner protein Sep15. Senior authors Daniel Hebert, professor of biochemistry and molecular ...

The School of Biochemistry was founded in 1964 by Professor Sir Philip Randle FRS who rapidly recruited many very able colleagues so that quickly the School of Biochemistry became one of the strongest ...

Apr. 8, 2025 — Scientists have pioneered an influenza virus vector-based nasal spray vaccine platform and developed a nasal spray H5N1 avian influenza vaccine. During the early COVID-19 pandemic ...

Snake puzzle models of protein folding and amyloid fibril formation. Protein folding under Anfinsen's dogma leads to a unique functional native structure. Protein misfolding out of Anfinsen's ...