生物通3 天
PROS1通过AKT/GSK3β/β-catenin通路抑制膀胱癌进展和血管生成的机制研究
该研究表明，PROS1 在膀胱癌中表达下调，与不良预后相关。PROS1 通过影响细胞增殖、侵袭、迁移和血管生成，在膀胱癌发展中起关键作用，其调控作用可能通过 AKT/GSK3β/β - catenin 信号通路介导。这一发现揭示了 PROS1 作为膀胱癌潜在治疗靶点的重要价值，为膀胱癌的治疗提供了新的方向。
Cytovation Appoints Martin Dewhurst to its Board of Directors
Brings over 30 years of life sciences industry experienceCo-led the McKinsey Global Life Sciences practiceBergen, Norway, ...
The Victoria Advocate1 个月
RiDYMO® Designs Cyclic Peptide for "Undruggable" β-Catenin Target Within Two Months
Hwang et al., Direct Targeting of b-Catenin by a Small Molecule Stimulates Proteasomal Degradation and suppresses Oncogenic Wnt/β-Catenin Signaling. 2016, Cell Rep. 16, 28–36. Tanton et al., ...
Cell polarity coordinates jellyfish larval development along a central axis, study finds
Scientists have uncovered a key mechanism in jellyfish embryos that provides new insights into how the body plan of these ...
EurekAlert!9 天
Cell polarity coordinates jellyfish larval development along a central axis
“In our previous research, we have shown that a protein called Wnt3 is stored on one side of the egg – the animal pole – in ...
Monthly Prescribing Reference2 天
Amezalpat Gets Fast Track Status for Hepatocellular Carcinoma
Amezalpat is an investigational oral, small molecule, selective peroxisome proliferator-activated receptor-alpha antagonist.
BioWorld14 天
Dewpoint nominates second condensate modulator for Wnt-driven cancers
Dewpoint Therapeutics Inc. has nominated a second development candidate, DPTX-3496. The oral, small-molecule condensate modulator targets β-catenin to address Wnt-driven colorectal cancer, ...