为探究头颈部鳞状细胞癌（HNSCC）中异常表观遗传重塑与肿瘤干性及化疗耐药的关系，研究人员开展了关于泛素特异性肽酶 10（USP10）作用机制的研究。结果发现 USP10/BAZ1A 轴可增强 HNSCC 干性、进展及化疗耐药，BAZ1A 抑制剂能抑制肿瘤。这为 HNSCC 治疗提供新靶点。

4月10日，上海交通大学研究团队在期刊《Cell Death&Disease》上发表了研究论文，题为“USP10 stabilizes BAZ1A to drive tumor stemness via an epigenetic mechanism in head ...

Liver diseases are a serious health problem worldwide, especially with a sustained increase in the burden of it every year. However, drugs commonly used in patients have limited efficacy and serious ...

Immunoprecipitation coupled with mass spectrometry (IP-MS) assays uncovered that ORMDL3 binds to USP10 (Ubiquitin-Specific Protease 10), which forms a complex with and stabilizes RIG-I through ...