为探究巴德 - 毕德综合征（BBS）中光感受器变性机制，研究人员用 iPSC 模型研究发现抑制 Chk2 激酶可延缓视锥细胞变性。 Bbs10-/-小鼠光感受器早期出现 DDR ：研究人员对野生型（wt）和 Bbs10 -/- 小鼠视网膜进行组织学分析，发现 P10 时，Bbs10 -/- 小鼠光感受器外核层（ONL）出现 DDR 激酶 p-Chk2 和组蛋白变体 γH2AX 积累，且在 P60 ...

IKKα-NEMO-ATM 复合物对受损 DNA 的识别，得益于 NEMO 与组蛋白之间的相互作用，并且依赖于 PARP1（Poly ADP - Ribose Polymerase 1）酶对组蛋白的 ADP 核糖基化作用。NEMO 缺陷细胞中激酶 ATR（Ataxia Telangiectasia and Rad3 - related）的活性增加，抑制 ATR 可增强化疗对缺乏 NEMO 或 ...

A team led by Prof. Wuran Wei from West China Hospital of Sichuan University and Dr. Dechao Feng from the Division of Surgery and Interventional Science at University College London has systematically ...

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The Malaysian Maritime Enforcement Agency (MMEA) has detained a cargo ship suspected of dumping waste oil in Selangor waters, ...

Bonus Jun 20, 2017-May 03, 2017 Bonus Ratio: 1 share(s) for every 10 shares held ...

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