Preclinical data further support the potential of dual-antigen and TGF-β-directed vaccines to reshape the tumor microenvironment and drive anti-tumor immunity NEW YORK, April 25, 2025 (GLOBE NEWSWIRE) ...

T-cell activation involves two phases, enabling a more precise immune response. This insight may boost cancer immunotherapy ...

Distinct proteolytic pathways share convergent activation patterns in many pathological contexts. Two new studies in Nature report on how effector memory-like CD8 + T cells infiltrate inflamed ...

Patients with spastic paraplegia type 15 develop movement disorders during adolescence that may ultimately require the use of ...

But before they can mount an effective response, the rare T-cells with the right specificity must undergo a process of activation, expansion, and specialization. This process—known as T-cell ...

Carl H. June, MD, the Richard W. Vague Professor in Immunotherapy in the Department of Pathology and Laboratory Medicine at ...

Data demonstrate potential superiority of antibody-based T cell engager CDR404 over TCR-based approaches, consistent with emerging Phase 1 trial signals of immunological activity and preliminary anti- ...

NOVEL lymph-node-inspired hydrogels enhance CAR T cell activation and proliferation by 50%, offering a more efficient and ...

CURE provides access to the cancer news, latest oncology research & expert insights that serve as a guide to every stage of ...

Scientists at Johns Hopkins Medicine have found a new role for a protein, QRICH1, which could become a target for drugs to dial up or down the activation of T cells to fight cancers and autoimmune ...