This work presents valuable data demonstrating that a camelid single-domain antibody can selectively inhibit a key glycolytic enzyme in trypanosomes via an allosteric mechanism. The claim that this ...

Department of Biomedical Chemistry, Faculty of Chemistry, University of Gdańsk, Gdańsk 80-308, Poland ...

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart – an important process for maintaining heart health. In the study ...

School of Environment and Energy Engineering, Gwangju Institute of Science and Technology (GIST), 123 Cheomdan-gwagiro, Buk-gu, Gwangju 61005, Republic of Korea Research Center for Innovative Energy ...

A superfamily of approximately 100 ubiquitin-specific proteases, called deubiquitylating enzymes, deubiquitinases ... however this is not always essential for activity, as exemplified in the ...

A new study has identified an enzyme that plays an important role ... for which USP5 is essential, for the first time. We assume that inhibiting the loss of USP5 or therapeutically increasing ...

Several proteins that have an essential role in autophagy have a direct ... Lenardo and co-workers showed that catalase, a key enzyme of the cellular antioxidant defence mechanism, was selectively ...

2019), but they do not clarify how the enzyme simultaneously ... an intriguing allosteric phenomenon in which the binding of alternative PAMs – such as AAG and GAT, but not TGG – induces a ...

Meiosis is a type of specialized cell division through which germ cells reduce their chromosome composition from diploid to haploid. Faithful completion of the first meiosis is therefore a critical ...

Cyclin-dependent kinases (Cdks) play an essential role in this coordination ... part of this perspective we will therefore further examine whether Sic1 has a direct effect on the enzyme activity of ...