The effects of caspases on cellular substrates bring about the biochemical and morphological features of apoptosis (Fig. 1). Caspase ... cleavage of poly (ADP-ribose) polymerase (PARP) and ...

The nuclear protein poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors have been proven effective to potentiate both chemotherapeutic agents and radiotherapy. However, a major problem of most current ...

Stablix Inc. has described new poly(ADP-ribose) polymerase 1 (PARP-1; ARTD1) inhibitors reported to be useful for the treatment of cancer.

Valo Health Inc. has disclosed poly(ADP-ribose) polymerase 1 (PARP-1; ARTD1) inhibitors reported to be useful for the treatment of cancer.

CADM1 can increase PARP-1 (poly ADP ribose polymerase) and recruit AIF (mitochondrial apoptosis inducing factor) and MIF (microphage migration inhibitory factor) to the nucleus, breaking down DNA into ...

Deregulated apoptosis may also be the leading cause of cancer therapy chemoresistance ... Some caspases have long prodomains containing special motif such as DED (caspase-8 and -10), and caspase ...

1 The FDA has approved PARP inhibitors olaparib, rucaparib, and niraparib to treat patients with ovarian cancer, and they are recommended as maintenance therapy for PSROC by both the American ...

Because a subset of these patients actually have DNA damage repair mutations, we know that adding a PARP inhibitor in the setting of progression has been associated with improvements in survival ...

21:16【美国1月ADP就业人数增加18.3万人】美国1月ADP就业人数增加18.3万人，前值为增加12.2万人。

美国1月ADP就业人数增加18.3万人，前值为增加12.2万人。 此内容为第一财经原创，著作权归第一财经所有。未经第一财经书面授权，不得以任何方式 ...