Their life expectancy is significantly reduced with an increased risk of malignancy and immune defects. Patients with variant A-T have reduced residual ataxia telangiectasia mutated (ATM) kinase ...

The newly allowed application covers the method of treating patients with Ataxia-Telangiectasia and provides patent coverage for preparing erythrocytes loaded with one or more substances of ...

The Schmitt family is grateful for the resources through A-T Children’s Project, as well as the love and care at St. Jude’s, ...

In addition to its function as an activator of type I IFN synthesis and autophagy, STING can also activate the NF-κB pathway in a TBK1-IKKϵ-dependent or TBK1-independent manner that involves DNA ...

"We had previously demonstrated that the p53 gene product--the most commonly mutated gene in human cancer--controls cell-cycle arrest in response to damage," says Kastan. In this paper the authors ...

1Department of Obstetrics and Gynecology, Peking University Third Hospital, China 2Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China. 3Biobank, Peking ...

Evidence for chemotherapy-induced cognitive changes comes from studies that have used neuropsychological testing, imaging (structural and functional magnetic resonance imaging (MRI) and positron ...

In the summer of 1977, Yosef Shiloh, then a graduate student, visited an Israeli Moroccan Jewish family with several children affected by ataxia-telangiectasia (A-T), a rare and complex genetic ...

Aging is the progressive loss of organ and tissue function over time. Growing older is positively linked to cognitive and biological degeneration such as physical frailty, psychological impairment, ...

Friedreich ataxia, an autosomal recessive neurodegenerative disease, is the most common of the inherited ataxias. The recent discovery of the gene that is mutated in this condition,FRDA, has led to ...

Wintering Monarch butterflies (Danaus plexippus), Santa Cruz, California. Masses of migrants gather in eucalyptus groves to overwinter before returning north; their numbers have decreased as a ...