In order to detect a vulnerable atherosclerotic plaque that is more likely to cause cardiovascular events, one should focus on studying biomarkers more associated with destabilization rather than ...

Atherosclerosis is a complex multifactorial pathology that progresses over many decades. Immune-inflammatory responses play key roles in all phases of the pathology and inflammation contributes to ...

HIF-1α exerts both detrimental and beneficial actions in atherosclerosis. While there is evidence that HIF-1α could be pro-atherogenic within the atheromatous plaque, experimental models of ...

In atherosclerosis, the vascular smooth muscle ... as well as to the formation of the fibrous cap that provides stability to the plaque. The VSMC can undergo a proliferative response that ...

IL-6 secreted by ECs, monocytes, T cells, neutrophils and VSMCs promotes adhesion molecule expression by ECs as well as transmigration of circulating immune cells into the atherosclerotic plaque (this ...

Amgen’s next-generation cholesterol drug has shown it can reverse the build up of plaque build-up in coronary ... significant regression of atherosclerosis in patients with coronary artery ...

Notch1 deficiency impairs the transcription of genes involved in mitochondrial fusion and biogenesis, thereby triggering aortic pathology. Early intervention to enhance these mitochondrial ...

w3 w4 Endothelial cell dysfunction is a key step in the initiation of atherosclerosis. The predilection for plaque formation at sites of arterial branching or bifurcation has identified disturbed ...

Exclusion criteria were poor image quality, intracranial arterial stenoses not atherosclerotic such as moyamoya disease or artery dissection ... OCT allows for a more accurate assessment of calcified ...